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You are studying a protein that you call Protein X. There is an aspartic acid at a key position in Protein X which is important in the folding and stabilization of that protein. If this aspartic acid is changed to a different amino acid, which type of amino acid substitutions is most likely to allow the protein to fold normally?

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wiseowl2018

Answer:

The same type of amino acid, means acidic amino acid substitution will leads to normal folding.

The amino acid will be glutamic acid.

Explanation:

  • Sometimes the amino acids of the same type substitution leads to normal proteins.
  • As the acidic group of aspartic acid is responsible for the folding of the protein .
  • So if the amino acid is substituted by glutamic acid, it will not leads to any abnormal protein folding.
  • Because glutamic acid also has a acidic group which is responsible for folding of protein.


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